Premiership winner David Stagg is set to play his first game for the Broncos this year, with Origin depleting the Brisbane team to take on the Knights at Hunter Stadium on Monday night.
Stagg will start in the second row, with Darius Boyd, Justin Hodges, Sam Thaiday, Matt Gillett and Corey Parker all away on Queensland duty.
With five players unavailable, Jordan Kahu shifts to fullback, Daniel Vidot comes in on the wing and Dale Copley joins the side at centre.
Jarrod Wallace will move to starting prop, while Jo Ofahengaue also starts at lock. Joe Boyce has been added to the bench.
Joe Tapine comes in for Beau Scott (New South Wales) in the only change for the Knights, who snapped a five-game losing streak against the Tigers on Sunday.
For the Cowboys against the Tigers at Campbelltown Stadium on Saturday night, Ray Thompson will start at halfback for Johnathan Thurston (Queensland).
Ben Hannant and Sam Hoare start in the front row for James Tamou (NSW) and Matt Scott (Maroons).
Rory Kostjasyn, Glenn Hall and Kelepi Tanginoa also join the side on the interchange.
For the Tigers, Matt Lodge starts in the front row for Aaron Woods (NSW), while Dene Halatau shifts to hooker to cover the absence of Blues No.9 Robbie Farah.
With Greg Inglis away on Origin duty at the Rabbitohs, Alex Johnston shifts to fullback and Joel Reddy returns on the wing, for the team's clash against Parramatta at ANZ Stadium on Friday night.
Will Hopoate (Blues) is replaced by Ryan Morgan at centre for the Eels, with John Folau coming in on the wing.
With Josh Morris, Trent Hodkinson, Josh Jackson and David Klemmer selected in the NSW side, Tim Lafai and Chase Stanley return in the centres for Canterbury against Canberra at GIO Stadium on Sunday.
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