UPDATE 4PM: A 53-YEAR-OLD man has been seriously injured in a three-vehicle collision north of Tyndale this afternoon.

A NSW Ambulance spokesman said paramedics treated the man and three others following the collision between a truck and two vehicles, which left a pantech truck flipped on its side.

"A 53-year-old male was taken to Lismore Base Hospital in a serious but stable condition," the spokesman said.

"Another man was treated for back pain, a 50-year-old woman was also treated by paramedics while a fourth person was uninjured."

UPDATE 2PM: The Pacific Highway has been cleared following a three-vehicle crash at Tyndale this afternoon.

Emergency services responded to the collision between a truck and two vehicles near Byrons Ln around 12pm today.

While the site has been cleared, Live Traffic NSW is advising motorists of continued heavy traffic conditions and to expect significant delays.

EARLIER: Emergency services have responded to a three-vehicle crash at Tyndale this afternoon, with traffic on the Pacific Highway has affected in both directions.

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According to LiveTraffic NSW, the collision between a truck and two vehicles happened about 12.06pm on the highway between Sheehys Ln and Byrons Ln, Tyndale.

Emergency services are currently at the scene, with heavy traffic conditions expected.

Motorists are advised to expect delays and exercise caution in the area. Alternating (stop/slow) traffic controls are currently in place.

Roads and Maritime Services is also attending a fallen tree which is blocking northbound traffic of the Pacific Highway near McIntyres Ln, Gulmarrad.